PXB-cells® applications

PXB-cells® are fresh human hepatocytes isolated from PXB-mouse®. We offer consistent delivery on your schedule and from the same donor source. We are proud to acknowledge that PXBcells® were used to generate scientific results for 10 presentations at HBV Meeting (International Hepatitis B Foundation – The molecular biology of Hepatitis B viruses) in Melbourne (Australia) and 4 presentations at AASLD Liver Meeting (American Association for the Study of Liver Diseases – 2019 Liver Meeting) in Boston. Selected publications using PXB-cells in various application areas are listed below:

PXB cells® were used to examine the efficacy of Japanese miso extracts as antiviral agents against #hepatitis A (#HAV):

Inhibitory effect of Japanese rice-koji miso extracts on hepatitis A virus replication in association with the elevation of glucose-regulated protein 78 expression.

Win N. et al. Int. J. Med. Sci. 2018; 15(11), 1153.

PXB-cells® were used to directly test the impact of PAPD5 and PAPd7 #mRNA knockdown on individual #HBV RNA types:

PAPD5/7 Are Host Factors That Are Required for Hepatitis B Virus RNA Stabilization.

Mueller H. et al. Hepatology 2019; 69(4), 1398.

PXB-cells® were transduced with various Adenovirus vectors, and protein expressions, genome editions and cell viabilities were analyzed (CRISPR):

Generation of the Adenovirus Vector-Mediated CRISPR/Cpf1 System and the Application for Primary Human Hepatocytes Prepared from Humanized Mice with Chimeric Liver.

Tsukamoto, T. et al. Biol. Pharm. Bull 2018; 41(7), 1089.

PXB-cells® were used in metabolites identification of fentanyl and its analogue

Use of hepatocytes isolated from a liver-humanized mouse for studies on the metabolism of drugs: application to the metabolism of fentanyl and acetylfentanyl.

Kanamori T. et al. Forensic Toxicol. 2018; 36(2), 467.

See more:  https://kmthepatech.com/pxb-cells/