Chimeric Mouse Model with
Highly Humanized Liver
Highly Humanized Liver
KMT Hepatech, Inc. is a part of PhoenixBio group since December 1, 2017
KMT Hepatech is a production facility of PhoenixBio Group products (PXB-mouse® and PXB-cells®) in North America.
PhoenixBio Group is utilizing its proprietary platform technology of small animal model of chimeric mouse with highly humanized liver, the PXB-mouse®.
The PXB-mouse® and PXB-cells® are your essential tools for therapeutics and vaccine development.
Commercial scale production of high quality chimeric mice
Always available for shipment
Stable engraftment for entire lifespan
Long-term applications – over 30 days in study
On-demand supply with consistent donor for in vitro reproducibility
Compatible with your preferred format including 3D
News and Events
Toxicity of Aflatoxin B1 in vitro and in vivo
The assessment of safety and the toxicity profile of chemical and biological entities remains a challenge. Despite ongoing efforts to better understand the mechanisms underlying safety and toxicity, ~30% of…
Oligonucleotides and the humanized liver mouse model
Oligonucleotides remain compounds of high interest in drug development, especially with recent advancements in chemistry and delivery technologies. With more compounds progressing further in preclinical development, the need for physiologically…
Hepatic effects of phenobarbital
Environmental Health laboratory of Sumitomo Chemical Company (Japan) published a paper “Comparison of the hepatic effects of phenobarbital in chimeric mice containing either rat or human hepatocytes with humanized constitutive…
Chimeric Mouse with Humanized Liver Consortium Publication
We are excited to share the Takeda team’s study results generated with the support of PhoenixBio through the Chimeric Mouse with Humanized Liver (CMHL) Consortium. The paper titled “Prediction of…
Mitochondrial toxicity in PXB-cells®
Mitochondrial toxicity is one of the pathogenic mechanisms of severe drug-induced liver injury (DILI). It is desirable to identify severe DILI risks early in development, however it is extremely difficult…
Fresh human hepatocytes for your research
PXB-cells® applications PXB-cells® are fresh human hepatocytes isolated from the PXB-mouse®. We offer consistent delivery on your schedule and from the same donor source. PXB-cells® are useful in many application…