The paper discusses lipoprotein profile and lipid metabolism of PXB-cells®, showing their suitability to screen anti-lipidemic agents. The authors show that PXB-cells® mainly release triglycerides and cholesterol as VLDL (similar to primary human hepatocytes) in contrast to two other hepatoma cell lines, which mainly release LDL (VLDL – very low density lipoprotein). Fenofibrate (PPARα ligand) suppressed lipoprotein production from PXB-cells® in a dose-dependent manner as shown by triglycerides and cholesterol profiles.