The comparative results of the most promising compound from the publication, compound 24, benchmarked against epacadostat showed significantly higher ratio of [AUC glucuronide]/[AUC parent]. (AUC is the area under the curve, and it reflects the actual body exposure to drug after administration of a dose of the drug.) Cmax was also few folds higher. So, the compound 24 had a significantly improved PK profile over epacadostat in PXB-mice with regard to hydroxyamidine glucuronidation.