PXB-cells®: Robust Human Hepatocytes

An open access paper providing a detailed characterization of PXB-cells® was published in late 2020 in PLoS ONE journal. These cells are proven to be a reliable in vitro…

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Figure 1. PXB-cells 12 days after plating. Yellow arrowheads indicate examples of bile canaliculi

Toxicity of Aflatoxin B1 in vitro and in vivo

The assessment of safety and the toxicity profile of chemical and biological entities remains a challenge. Despite ongoing efforts to better understand the mechanisms underlying safety and toxicity, ~30%…

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Toxicity of Aflatoxin B1 in vitro (PXB-cells) and in vivo (PXB-mouse)

Oligonucleotides and the humanized liver mouse model

Oligonucleotides remain compounds of high interest in drug development, especially with recent advancements in chemistry and delivery technologies. With more compounds progressing further in preclinical development, the need for…

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1001_Publications with PXB-mouse and PXB-cells in oligonucleotides studies

Hepatic effects of phenobarbital

 Environmental Health laboratory of Sumitomo Chemical Company (Japan) published a paper “Comparison of the hepatic effects of phenobarbital in chimeric mice containing either rat or human hepatocytes with humanized…

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Hepatic effects of phenobarbital in PXB-mouse

Mitochondrial toxicity in PXB-cells®

Mitochondrial toxicity is one of the pathogenic mechanisms of severe drug-induced liver injury (DILI). It is desirable to identify severe DILI risks early in development, however it is extremely…

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Mitochondria toxicity assessment with PXB-cells and Cryopreserved Human Hepatocytes

Species differences in liver accumulation and metabolism

 Species differences in liver accumulation and metabolism of nucleotide prodrug are discussed in the April 2020 publication by Gilead team.The difficulty in projecting human dose based on preclinical data…

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Gilead_Species differences in liver accumulation and metabolism of nucleotide prodrug_PXB-mouse and PXB-cells