Toxicity of Aflatoxin B1 in vitro and in vivo

The assessment of safety and the toxicity profile of chemical and biological entities remains a challenge. Despite ongoing efforts to better understand the mechanisms underlying safety and toxicity, ~30%…

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Toxicity of Aflatoxin B1 in vitro and in vivo
Toxicity of Aflatoxin B1 in vitro (PXB-cells) and in vivo (PXB-mouse)

Oligonucleotides and the humanized liver mouse model

Oligonucleotides remain compounds of high interest in drug development, especially with recent advancements in chemistry and delivery technologies. With more compounds progressing further in preclinical development, the need for…

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Oligonucleotides and the humanized liver mouse model
1001_Publications with PXB-mouse and PXB-cells in oligonucleotides studies

Hepatic effects of phenobarbital

Environmental Health laboratory of Sumitomo Chemical Company (Japan) published a paper “Comparison of the hepatic effects of phenobarbital in chimeric mice containing either rat or human hepatocytes with humanized…

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Hepatic effects of phenobarbital
Hepatic effects of phenobarbital in PXB-mouse

Mitochondrial toxicity in PXB-cells®

Mitochondrial toxicity is one of the pathogenic mechanisms of severe drug-induced liver injury (DILI). It is desirable to identify severe DILI risks early in development, however it is extremely…

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Mitochondrial toxicity in PXB-cells®
Mitochondria toxicity assessment with PXB-cells and Cryopreserved Human Hepatocytes

Fresh human hepatocytes for your research

PXB-cells® applications https://www.youtube.com/watch?v=uxGxs1nKoHE PXB-cells® are fresh human hepatocytes isolated from the PXB-mouse®. We offer consistent delivery on your schedule and from the same donor source. PXB-cells® are useful in…

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Fresh human hepatocytes for your research
Use of PXB-cells in DMPK-Toxicity, Hepatitis Studies, NASH-NAFLD, Gene Editing

International NASH Day 2020

International NASH Day - June 12 - is aimed to increase public awareness about non-alcoholic steatohepatitis (NASH). NASH is characterized by the presence of an abnormal accumulation of fat…

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International NASH Day 2020
NASH Day 2020