KMT Hepatech – 20 years

KMT Hepatech - 20 years February marks 20 years since KMT Hepatech (now part of the PhoenixBio Group) was incorporated. It has been a long journey and a great…

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KMT Hepatech – 20 years
Dr. N. Kneteman and Dr. L. Tyrrell receiving ASTech Foundation Award

PXB-cells®: Robust Human Hepatocytes

An open access paper providing a detailed characterization of PXB-cells® was published in late 2020 in PLoS ONE journal. These cells are proven to be a reliable in vitro…

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PXB-cells®: Robust Human Hepatocytes
Figure 1. PXB-cells 12 days after plating. Yellow arrowheads indicate examples of bile canaliculi

Toxicity of Aflatoxin B1 in vitro and in vivo

The assessment of safety and the toxicity profile of chemical and biological entities remains a challenge. Despite ongoing efforts to better understand the mechanisms underlying safety and toxicity, ~30%…

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Toxicity of Aflatoxin B1 in vitro and in vivo
Toxicity of Aflatoxin B1 in vitro (PXB-cells) and in vivo (PXB-mouse)

Oligonucleotides and the humanized liver mouse model

Oligonucleotides remain compounds of high interest in drug development, especially with recent advancements in chemistry and delivery technologies. With more compounds progressing further in preclinical development, the need for…

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Oligonucleotides and the humanized liver mouse model
1001_Publications with PXB-mouse and PXB-cells in oligonucleotides studies

Hepatic effects of phenobarbital

Environmental Health laboratory of Sumitomo Chemical Company (Japan) published a paper “Comparison of the hepatic effects of phenobarbital in chimeric mice containing either rat or human hepatocytes with humanized…

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Hepatic effects of phenobarbital
Hepatic effects of phenobarbital in PXB-mouse